Studies on Rabbit Lymphocytes in Vitro I. Stimitlation of Blast Transformation with an A_,ntiallotype by Stewart

The circulating lymphocyte has recently been reported to have many possible functions. Though once believed to be short-lived end cells (1), lymphocytes present in the peripheral blood are now known not only to recirculate for up to 5 days, but also to be capable of "homing" in lymph nodes and in the spleen (2). These cells have been reported to be capable of producing antibody (3), of transforming into plasma cells (4-6), of eliciting the graft versus host reaction (7, 8), of preventing the neonatal thymectomy wasting syndrome (9, 10), and in some situations of preventing the effects of lethal irradiation (11), and of repopulating the lymphoid tissues of irradiated animals (12).